姓名：袁超；科研实验中心负责人
学历：博士
职称：讲师
研究领域：遗传性疾病致病基因的筛选及其致病分子机制研究
代表性论著：
（1）Zhenxing Liu#，Mi Zhou#，Chao Yuan#，Zhengyi Ni，Wenqiang Liu，Yang Tan，Dazhi Zhang，Xiaopei Zhou，Tingting Zou，Jiarui Wang，Meiqi Hou，Xuejie Peng，Xianqin Zhang.Two novel STAT1 mutations cause Mendelian susceptibility to mycobacterial disease.Biochemical and Biophysical Research Communications.14 November 2021.https://doi.org/10.1016/j.bbrc.2021.11.036.
（2）Yuan C#, Su Z#, Liao S#, Li D, Zhou Z, Wang Y, Quan M, Zeng Z, Lv C, Shen C, Gong W, Wu J, Chen X, Wu W, Lv X, Si W*, Yu X*. miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5. Cancer Cell Int. 2021 Jul 21;21(1):390. doi: 10.1186/s12935-021-02092-7.
（3）Zhang Dazhi# ;Yuan Chao# ; Liu Mengxue# ; Zhou Xiaopei; Ge Shunnan Wang Xuelian; Luo Geng; Hou Meiqi; Liu Zhenxing; Qing K. Wang; Wang Xu; Li Haohong;Tan Yang; Jia Weimin; Wang Jiarui; Wu Yanling; Wang Ali; Yang Xiaofei; ZhangXianqin* ; Deficiency of SCAMP5 leads to pediatric epilepsy and dysregulation of neurotransmitter release in the brain, Hum Genet, 2020, 139(4): 545-555.
（4）Wang, Zhaoxing# ;Yuan Chao#; Huang Yuan; Liu Zhenxiang; Yu Xin; Lv Cai*; Su Zhenhong*; Decreased expression of apoptosis-inducing factor in renal cell carcinoma is associated with poor prognosis and reduced postoperative survival , Oncology Letters, 2019, 18(3): 2805-2812.
（5）Yuan Chao#; Han Tiantian #; Su Pan ; Liu Min; Zhou Xiaopei; Zhang Dazhi;Jia Weimin; Wang Ali; Yue Min; Xiang Zibing; Chen Liming ; Zhang Xianqin ; A novel MIP mutation in a Chinese family with congenital cataract , Ophthalmic Genetics, 2018, 39(4): 473-476.
（6）Zhang Xianqin#; Bogunovic Dusan# ; Payelle Brogard Beatrice#; FrancoisNewton Veronique#; Speer Scott D;Yuan Chao; Volpi Stefano; Li Zhi; Sanal Ozden;Mansouri Davood; Tezcan Ilhan; Rice Gillian I; Chen Chunyuan; Mansouri Nahal;Mahdaviani Seyed Alireza; Itan Yuval; Boisson Bertrand; Okada Satoshi; Zeng Lu;Wang Xing; Jiang Hui; Liu Wenqiang; Han Tiantian; Liu Delin; Ma Tao; Wang Bo;Liu Mugen; Liu Jing Yu; Wang Qing K; Yalnizoglu Dilek; Radoshevich Lilliana; Hu man intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation, Nature, 2015, 517(7532): 89-U229.
（7）Deng Xiaoling#; Xu Mingyan# ;Yuan Chao; Yin Liqin; Chen Xihe; ZhouXiaoqiong; Li Guanwu; Fu Yucai; Feghali Bostwick Carol A; Pang Linhua; Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-kappa B and activator protein-1 , INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 2013, 45(7): 1366-1376.
（8）Wenxia Si, Bisheng Zhou, Wen Xie, Hui Li, Ke Li, Sisi, Li, Wenbing Deng, Pengcheng Shi,Chao Yuan, Tie Ke, Xiang Ren, Xin Tu, Xiaomei Zeng, Britta Weigelt, Brian P Rubin, Qiuyun Chen, Chengqi Xu, and Qing Kenneth Wang.Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2. Cancer Letters.2021 Jan 28;497:28-40.
（9）Huang Yuan#; Wang Zhijie#; Liu Yinan; Xiong Hongbo; Zhao Yuanyuan;Wu Ling;Yuan Chao; Wang Longfei; Hou Yuxi; Yu Gang; Huang Zhengrong; Xu Chengqi; Chen Qiuyun*; Wang Qing K*, alphaB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5. J Biol Chem, 2016.5.20, 291(21): 11030~11041.
（10）Yuan Chao *; Liao Yanli*; Liao Shengjie ; Huang Mi ; Li Duanzhuo ; Wu Weibin ; Quan Yi ; Li Liqiang ; Yu Xin ; Si Wenxia ; Triptolide inhibits the progression of Glioblastoma U251 cells via targeting PROX1, Frontiers in Oncology,2023, 13.
（11）Liao Shengjie; Huang Mi; Liao Yanli; Yuan Chao; HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production, Curent Eye Research, 2023,48: 25-33.
（12）Yanli Liao* , Chao Yuan* , Mi Huang, WenXia Si, Duanzhuo Li , Weibin Wu , Shifa Zhang, Runkun Wu, Yi Quan, Xin Yu, Shengjie Liao ；AZD7762 induces CRBN dependent BAG3 degradation through ubiquitin-proteasome pathway；Anticancer Drugs. 2024 Jan; 35(1): 46–54.
主持或参加科研项目（课题）情况:
(1) 广东省基础与应用基础研究基金委员会, 广东省自然科学基金面上项目, 2023A1515010239, FBXO28识别并调控AGGF1蛋白在肾癌发生和转移中的作用及分子机制研究, 2023-01 至 2025-12, 10万元, 在研, 参与。
(2) 广东省卫生健康委员会, 广东省医学科研基金项目, A2022056, SCAMP5 R91W突变介导癫痫疾病发生的分子机制研究, 2022-07 至 2024-06, 2万元, 在研, 主持。
（3）肇庆医学高等专科学校2022年中青年科技基金项目，2022-01 至 2025-12，10万元，在研，主持。
