姓名：廖生洁

学历：博士

职称：讲师

研究领域：人类医学遗传学，以及蛋白质翻译后修饰与疾病发生

代表性论著：

（1）Liu P#, Cong X#,Liao S#, Jia X#, Wang X, Dai W, Zhai L, Zhao L, Ji J, and Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, and Liu B, Tan M. Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ. 2021 Jul 2. doi: 10.1038/s41418-021-00827-7.

（2）Yuan C#, Su Z#,Liao S#, Li D, Zhou Z, Wang Y, Quan M, Zeng Z, Lv C, Shen C, Gong W, Wu J, Chen X, Wu W, Lv X*, Si W*, Yu X*. miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5. Cancer Cell International 2021 Jul 21;21(1):390.

（3）Liu B, Zhang Z, Hu Y, Lu Y, Li D, Liu J,Liao S, Hu M, Wang Y, Zhang D, Chen Y, Qian Q, Lv X, Wu D, Tan M, Hu C, Xiong X, Li X. Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14. Proceedings of the National Academy of Sciences of the United States of America. 2019;116:21732-8.

（4）Jiao Y,Zhao J,Zhang Z,Li M,Yu X,Yang Y,Liu J,Liao S,Li D,Wang Y,Zhang D,Chen Y,Shi G,Liu B*,Lu Y*,Li X*. SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c.Diabetes.2018 Nov;67(11):2227-2238.

（5）JinL#,ChenD#,LiaoS#,ZhangY,YuF,WanP,YuD,WuQ,ZhangY. Transcriptome analysis reveals downregulation of virulence-associated genes expression in a low virulence Verticillium dahliae strain. Arch Microbiol. 2019 Sep;201(7):927-941.

（6）Zheng X#Wu K#,Liao S,Pan Y,Sun Y,Chen X,Zhang Y,Xia S,Hu Y,Zhang J*. MicroRNA-transcription factor network analysis reveals miRNAs cooperatively suppress RORA in oral squamous cell carcinoma.Oncogenesis.2018 Oct 8;7(10):79.

（7）Liao S, Qu Z, Li L, Zhou B, Gao M, Huang M*, Li D*. HSF4 transcriptional regulates HMOX-1 expression in HLECs. Gene 2018; S0378-1119(18)30169-0.

（8）Liao S, Du R, Wang L, Qu Z, Cui X, Li C, Liu F, Huang M, Wang J, Chen J, Gao M, Yu S, Tang Z, Li DW, Jiang T*, Liu M*. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. The international journal of biochemistry & cell biology. 2015;68:78-86.

（9）Liu W, Li X,Liao S, Dou K, Zhang Y. Activation of the intronic cryptic 5' splice site depends on its distance to the upstream cassette exon. Gene. 2017;619:30-6.

（10）Jin L#, Li G#, Yu D*, Huang W, Cheng C,Liao S, Wu Q, Zhang Y*. Transcriptome analysis reveals the complexity of alternative splicing regulation in the fungus Verticillium dahliae. BMC genomics. 2017;18:130.

（11）Gao M#, Huang Y#, Wang L#, Huang M, Liu F,Liao S, Yu S, Lu Z, Han S, Hu X, Qu Z, Liu X, Assefa Yimer T, Yang L, Tang Z, Li DW*, Liu M*. HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell death & disease. 2017;8:e3082.

（12）Wang J#, Liu Y#, Liu F#, Huang C, Han S, Lv Y, Liu CJ, Zhang S, Qin Y, Ling L, Gao M, Yu S, Li C, Huang M,Liao S, Hu X, Lu Z, Liu X, Jiang T, Tang Z, Zhang H, Guo AY*, Liu M*. Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis. Scientific reports. 2016;6:24226.

（13）Gao M#, Zhang S#, Liu C#, Qin Y, Archacki S, Jin L, Wang Y, Liu F, Chen J, Liu Y, Wang J, Huang M,Liao S, Tang Z, Guo AY, Jiang F*, Liu M*. Whole exome sequencing identifies a novel NRL mutation in a Chinese family with autosomal dominant retinitis pigmentosa. Molecular vision. 2016;22:234-42.

（14）Liu F#, Chen J#, Yu S#, Raghupathy RK, Liu X, Qin Y, Li C, Huang M,Liao S, Wang J, Zou J, Shu X, Tang Z*, Liu M*. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Human molecular genetics. 2015;24:4648-59.

（15）Huang M#, Li D#, Huang Y#, Cui X,Liao S, Wang J, Liu F, Li C, Gao M, Chen J, Tang Z, Li DW*, Liu M*. HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53. Biochimica et biophysica acta. 2015;1853:1808-17.

（16）Chen J#, Liu F#, Li H#, Archacki S, Gao M, Liu Y,Liao S, Huang M, Wang J, Yu S, Li C, Tang Z*, Liu M*. pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation. Cellular signalling. 2015;27:2314-23.

（17）Li C#, Wang L#, Zhang J#, Huang M, Wong F, Liu X, Liu F, Cui X, Yang G, Chen J, Liu Y, Wang J,Liao S, Gao M, Hu X, Shu X, Wang Q, Yin Z, Tang Z*, Liu M*. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochimica et biophysica acta. 2014;1842:1121-9.

（18）Cui X#, Wang L#, Zhang J#, Du R,Liao S, Li D, Li C, Ke T, Li DW, Huang H, Yin Z, Tang Z*, Liu M*. HSF4 regulates DLAD expression and promotes lens de-nucleation. Biochimica et biophysica acta. 2013;1832:1167-72.

主持或参加科研项目（课题）情况:

2019年湖北省自然科学基金青年基金，HSF4在晶状体上皮细胞中的抗氧化功能研究，项目资助金额5w，主持项目，已结题。